Inflammation of prolonged duration measured in weeks to months in which discharge, tissue injury and attempts at repair coexist in varying combinations.
May fol down(p) intense inflammation or may begin as a low grade smouldering response without any manifestations of an acute reaction.
The irregular type is the cause of tissue damage in change diseases like RA, atherosclerosis, TB etc.
alike implicated in the procession of cancer and neurodegenerative diseases.
CAUSES:
Persistent infection Mycobacterial, fungi, parasites. Difficult to eradicate. The organisms start a delayed type of hypersensitivity. Evoke a granulomatous response.
resistive mediated inflammatory diseases Excessive and inappropriate activation of the immune system.
May develop against the individuals own tissues leading to autoimmune diseases.
autoimmune diseases evoke a self perpetuating immune reaction that results in chronic tissue damage and inflammation.
RA and multiple sclerosis.
hypersensitised diseases like bronchial asthma.
May doom both an acute and chronic inflammatory pattern. IN the later stages, may show fibrosis.
Prolonged exposure to toxic agents Maybe exogenous or endogenous.
Particulate silica. Causes silicosis.
Atherosclerosis caused by endogenous toxic germ plasm lipid comp unmatchablents.
MORPHOLOGICAL FEATURES :
Infiltration by mononuclear cells.
thread destruction.
Attempts at healing by connective tissue transposition of damaged tissue, angiogenesis and fibrosis.
ROLE OF MACROPHAGES IN CHRONIC INFLAMMATION:
predominant cell in chronic inflammation.
Component of the mononuclear macrophage system.
Also called the Reticulo Endothelial system.
Closely related cells of bone marrow origin. set in different organs and tissue different names.
female genitalia from a common precursors in the bone marrow which gives swot to monocytes.
Migrates to different tissues to form macrophages.
Half life of a monocyte is one day. Half life of a macrophage is...If you want to get a full essay, order it on our website: Ordercustompaper.com
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